Design and evaluation of bilayered buccal film preparations for local administration. How many believe tongue tie can cause speech difficulty in some. Formulation and evaluation of mucoadhesive buccal patch of acyclovir utilizing inclusion phenomenon 889 swelling index the swelling index was measured using the diameter method. Formulation and evaluation of buccal patches of diclofenac. The patches were evaluated for weight and thickness, content uniformity, surface ph, swelling, in. Formulation and in vitro evaluation of xanthan gumbased. A novel bilayered mucoadhesive buccal patch of zolmitriptan was prepared using xanthan gum xg as mucoadhesive polymer. The lips, tongue, and buccal mucosa are the most common areas affected. In the present study, matrix based bilayered buccoadhesive patches were developed and evaluated for in vitro drug permeation studies, buccal absorption, in vitro drug release, moisture absorption, mechanical properties, surface ph studies, in vitro bioadhesion and stability in human saliva. Preclinical evaluation of novel mucoadhesive bilayer patches for. Linea alba bite marks arises as a white line on the buccal mucosa, and sometimes the side of the tongue, and can be confused with lichen planus. Hairy leukoplakia is a type of leukoplakia caused by the epsteinbarr virus.
Formulation and evaluation of buccal patches of diclofenac sodium. Burning mouth syndrome, or burning tongue syndrome, can cause this sensation on your tongue or in other areas of your mouth, like the inside of your cheeks, gums, lips, or palate. Formulation and in vitro evaluation of bilayered buccal. A 67 year old woman has a chronic sore mouth of 2 years duration. Red lesions of the oral mucosadifferential diagnosis, clinical features and treatment. Adherent white plaques were noted on the dorsal tongue and buccal mucosa. Leukoplakia is a white or gray patch that develops on the tongue, the inside of the cheek, or on the floor of the mouth. Gelatin and polyvinyl pyrrolidone pvp k30 were incorporated into the patches, to improve the film properties of the patches. Read formulation and in vitro evaluation of xanthan gumbased bilayered mucoadhesive buccal patches of zolmitriptan, carbohydrate polymers on deepdyve, the largest online rental service for scholarly research with thousands of academic publications available at your fingertips. The lesions usually occur on the buccal mucosa and the labial and oral vestibule, but the floor of the mouth, ventral tongue, soft palate, and gingiva may be also. The main aim of buccal drug delivery of the drug as potential therapeutic agent is there instability in. Subjects were instructed to place patches two times daily, directly on olp lesions as instructed at enrollment.
The crosslinking of cs with plp allows further control of the system swelling and, hence, of the drug release and mucoadhesive properties. The patches were prepared by the solvent casting method. Two methods, namely, solvent casting method and direct milling are used to prepare adhesive patches. The present study was an attempt to develop and evaluate mucoadhesive bilayered buccal patches to ensure satisfactory unidirectional release of montelukast sodium ms. Pdf mucoadhesive bilayer buccal patches of verapamil. Original article mucoadhesive bilayer buccal patches of verapamil hydrochloride. White patch on buccal mucosa doctor answers on healthcaremagic. The buccal patch designed in a matrix configuration contains drug, adhesive, and additives mixed.
The purpose of this study was to develop and optimize formulations of mucoadhesive bilayered buccal patches of sumatriptan succinate using chitosan as the base matrix. Red lesions of the oral mucosadifferential diagnosis. The area of absorptive membrane is relatively smaller. Formulation and characterization of buccal mucoadhesive patch of chlorhexidine gluconate deepak s. Oral surfaces frequently exposed to trauma may develop the pigmentation more frequently.
An ex vivo evaluation of the bilayered tablets in natural human saliva. Mucoadhesive bilayered patches for administration of. Advances in nanoparticulate drug delivery approaches for. Webmd symptom checker helps you find the most common medical conditions indicated by the symptoms white patches on tongue including thrush infants and children and thrush adults. Advances in oral transmucosal drug delivery university of. Sushma gopal sree dattha institute of pharmacy, sheriguda, ibrahmipatnum, hyderabad abstract the main objective of present study was to design and evaluate the muco adhesive buccal patch. Apr 10, 20 administering the drug via membrane located below the tongue is called sublingual ddssldds generally called floor of mouth. Formulation and in vitro evaluation of bilayered buccal patches of a proton pump inhibitor. Fentanyl may also cause severe, possibly fatal, breathing problems. Alveolar mucosa, the lining between the buccal and labial mucosae.
The backing membrane was prepared by using sodium alginate. Totstethered oral tissues the assessment and diagnosis of. The sublingual and buccal routes of administration have significant advantages for both local and systemic drug delivery. Oral patches are usually laminates consisting of an impermeable backing layer. They must also possess good mucoadhesion in order to be retained in the mouth for the desired duration. More advanced drug delivery systems include films, patches, bilayer tablets. Cassidy j, berner b, chan k, john v, toon s, holt b, et al. However, they will not dissolve completely in your mouth and must be removed after 12. Drugs can be rapidly and directly absorbed into the systemic circulation via venous drainage to the superior vena cava.
Formulation and evaluation of buccal patches of simvastatin. Although the white color in leukoplakia is a result of hyperkeratosis or acanthosis, similarly appearing white lesions that are caused by reactive keratosis smokers keratosis or frictional keratoses e. Bilayerd films were prepared by solvent casting technique using different concentration of two polymers namely, sodium alginate and pectin. The constant rubbing of the mucosa may cause white patches that can disappear if. To develop mucadhesive bilayer buccal patches of verapamil. Whitish papules and plaques on the tongue photo quiz. Preparation of mucoadhesive oral patches containing tetracycline.
Universidade do minho, buccal tablets of flurbiprofen suspensions gt capsules. The bilayered patches were prepared using ethyl cellulose as a. Recent approaches in buccal patches the pharma innovation. Buccal patch designed for bidirectional drug release 2. Mucoadhesive patch were weighed individually x 0 and placed separately in 2% agar gel plates and incubated at 370c10c. Fda approves belbuca buprenorphine patch october 27, 2015 a new buccal film patch, designed to fit flexibly on the inner cheek, has been approved by the us food and drug administration as a longacting schedule iii opioid therapy for chronic pain patients. The present study has been designed on the basis of all these desirable properties for buccal patches. The surface texture of buccal patches was smooth and uniform. Because of the properties such as hydrophobicity, low water permeability, drug impermeability, and moderate flexibility, ethyl cellulose was used as a. The floor of the mouth is in continuity with the tongue, thats anterior twothirds occupy the oral cavity. For development of mucoadhesive, bilayered buccal patches of sumatriptan succinate, chitosan was used as base matrix polymer 7,8.
Buccal patches, felodipine, bioadhesion, mechanical properties, buccal delivery introduction buccal delivery of drugs provides an attractive alternate to the oral route of drug administration, particularly in overcoming deficiencies associated with the oral. It is often due to poor oral hygiene which leads to accumulation of oral bacteria and build up of keratin on the tongue surface. Fentanyl buccal is placed inside the mouth between the cheek and gum. Development of bilayered mucoadhesive patches for buccal delivery of felodipine. Robert davidson and jessica rousset explain how buccal administration further. Early squamous cell carcinoma presenting as a red patch on the tongue. The patches on the tongue are caused by an absence of papillae or tiny bumps in the affected area. Black hairy tongue is a harmless condition which causes blackening pigmentation on the dorsum of the tongue. Abstract buccal patches of omeprazole were prepared by solvent evaporation method using hpmc e15, polyvinyl alcohol and eudragit which are the hydrophilic polymers in different ratios. Colour of the patches changes from white to yellowish white as we go on increasing the concentration of chitosan from 33.
Formulation and evaluation of metformin hydrochloride buccal. The diagnosis is based on the history and the clinical features. They have shown to be an effective alternative to the traditional oral route, especially when fast onset of action is required. Characteristic findings are a white lacework pattern. Yadav2 1dstsms college of pharmacy, solapur, maharashtra 404,india. This thesis after intranasal torres lugo and jelly sandwich writing paper.
Buccal mucosa, buccal patchfilm, permeation, transmucosal. Bidirectional figure 1 patches release drug in both the mucosa and the mouth. The present study, in addition, describes bioavailability study in new zealand white rabbits to. A novel mucosal adhesive film called zilactin consisting of an alcoholic. A clinical perspective on mucoadhesive buccal drug delivery systems. The different types of oral mucosa include the lining mucosa inner lips, cheeks, soft palate, floor of the mouth, alveolar process, keratinized mucosa gum and hard palate, and specialized mucosa dorsum of the tongue. Buccal patches consists of two laminates, with an aqueous solution of the adhesive polymer being cast onto an impermeable backing sheet, which is then cut into the required oval shape. The patches were prepared using hpmc k4m as a polymer.
The drug containing layer was prepared by using pectin. It often affects people with a weakened immune system, particularly those with hiv and aids or who have had an organ transplant and are taking immunosuppressant medication it causes fuzzy white patches, often on the sides of the tongue, that look folded or ridged. Introduction n pharmaceutical area, patches are gained importance due to novel, patient convenient. Human transbuccal absorption of diclofenac sodium from a prototype hydrogel delivery device. See your doctor right away if you have patches with red spots. Nov 05, 2019 a number of advances in drug formulation have been made in the area of sublingual and buccal drug delivery.
Arch pharm res vol 34, no 10, 17011710, 2011 doi 10. Fentanyl has a risk for abuse and addiction, which can lead to overdose and death. Development of bilayered mucoadhesive patches for buccal. The mean thickness of buccal polymeric patches increased. For the preparation of patches commonly used technique is solvent casting technique. A novel mucosal adhesive film called zilactin consisting of an alcoholic solution of hydroxy propyl cellulose and three organic acids. It also contains many sensory receptors including the taste receptors of the tongue 1,2. Leukoplakia, oral definition of leukoplakia, oral by. Formulation and evaluation of mucoadhesive buccal patch of.
A clinical perspective on mucoadhesive buccal drug delivery. Mucoadhesive bilayered buccal patches of metoprolol tartarate were formulated using chitosan as the mucoadhesive polymer and the base matrix for the drug. Oct 27, 2015 fda approves belbuca buprenorphine patch october 27, 2015 a new buccal film patch, designed to fit flexibly on the inner cheek, has been approved by the us food and drug administration as a longacting schedule iii opioid therapy for chronic pain patients. Mar 01, 2015 abstractthe roll of tethered oral tissues tots such as an infants tongue and upper lip attachment are often overlooked or dismissed as cause of infant distress or maternal discomfort during breastfeeding. Bilayer films have been evaluated for the mucosal immunization of rabbit via the buccal. Although the systems look like tablets, you should not chew or swallow them. The thickness and weight of the films were found to be uniform as indicated by the low values of standard deviation. Oct 14, 2012 buccal formulationbuccal tablets buccal patches most commonly investigated laminates consisting of an dosage form for buccal drug impermeable backing layer, a tablets are small, flat, and oval, drugcontaining reservoir layer, a with a diameter of approximately bioadhesive surface for mucosal 58 mm attachment tablets can be. It showed significant bioadhesive properties with an optimum release profile and could be useful for buccal delivery. It is the mouths reaction to chronic irritation of the mucous membranes of the mouth. The patches were designed to release the drug for a prolonged period of time so as to reduce the frequency of administration of the available conventional dosage forms of ms. If the effective area for absorption is dictated by the dimensions of a delivery system. Fentanyl buccal sublingual is an opioid pain medicine used to treat breakthrough cancer pain that is not controlled by other medicines. Among the various transmucosal routes, buccal mucosa has excellent accessibility and relatively immobile mucosa, hence suitable for administration of retentive dosage form.
Movement of the tongue can cause dislodging of the patch. Mucoadhesive bilayer buccal patches of verapamil hydrochloride. The buccal drug delivery systems easily administered into the buccal cavity. The oral cavity comprises the lips, cheek, tongue, hard palate, soft. In vitro, ex vivo and in vivo characterization, archives of pharmacal research on deepdyve, the largest online rental service for scholarly research with thousands of academic publications available at your fingertips.
Literature studies on preparation and evaluation of buccal. Buccal tablets, soluble film are you currently presently presently interest about on buccal tablets for the buccal area the author in pdf page link. Transmucosal delivery of domperidone from bilayered buccal. The appearance of a white coating is caused by debris, bacteria and dead cells getting lodged between the enlarged and sometimes inflamed papillae. A clinical perspective on mucoadhesive buccal drug. The latter appears as multiple, flat, irregularly shaped, serpiginous red patches with raised keratotic rims that heal spontaneously and reappear in constantly changing patterns. Types of white lesions divided based on scrapping off feature. Oral mucosa can be divided into three main categories based on function and histology. The buccal patch designed in a reservoir system contains a cavity for the drug and additives separate from the adhesive. Formulation and characterization of buccal mucoadhesive patch. Fentanyl buccal or sublingual products are used in the mouth but not swallowed whole. How many people believe they currently have or have had a patientchild with tongue tie. Successful resolution of problems and understanding of these two. Formulation and evaluation of buccal patches of diclofenac sodium shubhra pandey abstract.
Design and evaluation of chitosanethylcellulose mucoadhesive. Preexisting melanosis was identified in about a third of the cases. The lesions consist of multiple persistent ulcers adjacent to white rough thickened areas which do not rub off and are arranged in a striated pattern. Testosterone buccal systems will soften and mold to the shape of your gum and will gradually release medication. An investigation to assess adhesion time, tolerability and. Drugs administered via the sublingual and buccal routes are traditionally. At the weekly clinic visit, patch adhesion time, tolerability and usability of the plain patches. The research paper published by ijser journal is about formulation and evaluation of buccal patches of diclofenac sodium 7. Generally factors affecting the sldds are almost similar to factors related with the bdds. In 2010 work on development of bilayered mucoadhesive patches for buccal delivery of felodipine. Bilayered transmucosal drug delivery system of pravastatin. Lining mucosa, nonkeratinized stratified squamous epithelium, found almost everywhere else in the oral cavity, including the.
There are 2 conditions associated with white patches on tongue. Another group of scientists had done work on development of mucoadhesive patches for buccal administration of ibuprofen. Oromucosal film preparations for pharmaceutical use formulation. Buccal patches must be flexible, elastic and strong to withstand the mechanical activity inside the mouth. A shallow crusted erosion was also noted on the middle of the lower lip. Bilayered buccal patches were developed by solvent casting technique and evaluated for in vitro drug release, moisture absorption, mechanical properties, surface ph, in vitro bioadhesion, in vivo residence time and ex vivo permeation of dom through porcine buccal membrane from a bilayered buccal patch. Buccal patches offer greater flexibility and comfort than adhesive tablets and a monolayered buccal patch was chosen for development in. The bilayered buccal patch was carefully removed from petridish and checked for any imperfection and cut according to size rectangle film 1 cm in length and 2 cm in width so that each patch contained 4 mg of the drug. The novel buccal dosage forms exhibits better patient compliance. The mucoadhesive polymers are to be incorporated to keep dosage form at buccal region for long periods to withstand tissue movements during talking and if possible during eating food or swallowing. Testosterone buccal systems only work when applied to the upper gum. Eightyeight lesions occurred on the palate, 46 on the maxillary gingiva, 18 on the buccal mucosa, 10 on the lip, 9 on the mandibular gingiva, 6 on unspecified gingiva, 4 on the tongue, and 1 on the floor of the mouth figure 7. Structure of oral cavity buccal patches buccal patch is a nondissolving thin matrix modifiedrelease dosage form composed of one or more polymer films or layers containing the drug andor other excipients. Differential diagnosis of white lesion of oral cavity.
Bilayered buccal tablets thesis writing i help to study. Advances in nanoparticulate drug delivery approaches. Ethyl cellulose, carbopol 934, mucoadhesion, oral infections. Research article formulation and characterization of. The treatment period was four weeks with weekly visits to the clinic. The aim of present investigation was to design and evaluate, mucoadhesive buccal patch of metformin hydrochloride, a bcs class ii drug, to provide unidirectional sustained drug delivery to the buccal mucosa that has potential to enhance the bioavailability. The buccal patches prepared using 50% glycerine ww of polymer weight were found to have good physical characteristics. White tongue is the result of an overgrowth and swelling of the fingerlike projections papillae on the surface of your tongue. Leukoplakia can occur on your gums, the inside of your cheeks, under or on your tongue. Read transmucosal delivery of domperidone from bilayered buccal patches. The impermeable backing layer was of ethyl cellulose to ensure a unidirectional drug release. Two types of new buccal bilayered devices based on cs as an adhesive polymer were prepared, which are suitable for achieving sustained release of either hydrophilic or lipophilic drugs. Sumatriptan succinate mucoadhesive bilayered aceclofenac mucoadhesive buccal 3. Bilayered buccoadhesive patches for buccal delivery of felodipine could be prepared.
Tongue tie and other tethered oral tissues what do we know and where do we go. Has anyone ever wondered why we, as a field, ignore tongue tie. A corresponding increase in the mucoadhesive strength of patches was observed with increase in concentration of chitosan. It is a very common oral condition and affects % of the world population. Hydroxypropyl methylcellulose e15 was used as filmformer and polyvinyl alcohol pva was incorporated, to increase the tensile strength of the patches. Buccal region of oral cavity shows less active movements. Leukoplakia is a white or gray patch that develops on the tongue or the inside of the cheek. Formulation and evaluation of a bioadhesive patch for buccal. The sldds is almost similar to the bdds having some more advantages than buccal drug delivery system. Mucoadhesive bilayered buccal patches of vph were formulated using solvent casting. Buccal patches are described as laminates which comprise of an impermeable backing layer, a drugcontaining reservoir layer which releases the drug in a controlled manner, and a bioadhesive surface for mucosal attachment. An exvivo evaluation of the bilayered tablets in natural human saliva.
Bilayered buccal patches of a proton pump inhibitor pradeep kumar koyi department of pharmaceutics, krupanidhi college of pharmacy, bangalore560 035, india. Moreover, the studies performed until now on the buccal delivery system tablet of the drug are confined to the ex vivo assessment of the developed system. The tongue can also be involved, and less so the gums and lips. Leukoplakia patches can also develop on the female genital area. From the present study carried out on simvastatin buccal patches prepared from 1% eudragitrs100 and variable amount of different polymer composite, pvp, pva, hpmc and ec. The research paper published by ijser journal is about formulation and evaluation of buccal patches of diclofenac sodium 3 issn 22295518 the plasticized sodium alginate solution was poured into a petridish and solvent was allowed to evaporate at room temperature by covering the petridish with inverted glass funnel, to avoid blistering effect. The lesions are bilateral and involve the buccal mucosa, lateral borders of the tongue. Frontiers advances in nanoparticulate drug delivery.
Leukoplakia could be classified as mucosal disease, and also as a premalignant condition. In the mouth the buccal mucosa is the most commonly affected site. Mechanical strength test for orodispersible and buccal films. Evaluation of bilayered mucoadhesive buccal patch 1417. Because of the properties such as hydrophobicity, low water permeability, drug impermeability, and moderate flexibility, ethyl cellulose was used as a backing layer polymer. Design and evaluation of buccal patches of granisetron. While interviewing and examining a 17yearold male, i discovered a white patch on his buccal mucosa and slanting palpebral fissures in his eyes.
1362 436 243 813 435 1080 756 828 1676 1637 1402 958 768 1404 1127 749 666 1090 812 1682 1321 293 531 947 363 408 278 35 645 732 27 1461 1472 560 207 161 322 1472 414 841 1237 299 641 801